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. 2013 Mar 7;49(5):858–871. doi: 10.1016/j.molcel.2013.01.002

Figure 2.

Figure 2

A Requirement for RIF1 in the NHEJ of Dysfunctional Telomeres

(A) Western blot showing comparable expression of indicated Trf2 transgenes between MEF lines of the indicated genotype.

(B) Metaphases were analyzed for telomere end-to-end fusions in cells of indicated genotype, 96 hr following retroviral transduction of the indicated TRF2 expression constructs. Right panels show enlargement of corresponding left panel. Telomeric fluorescence in situ hybridization (FISH), red; 4,6-diamidino-2-phenylindole (DAPI), gray.

(C) Quantification of chromosome fusions. n = 3,000, 2,000, and 3,000 chromosomes scored per genotype, over two independent experiments. ∗∗∗p < 0 .0001 (one-way ANOVA). Error bars are ± SEM.