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. 2013 Mar 12;3:1431. doi: 10.1038/srep01431

Figure 7. Sensitivity of the optical diagnostic method based on the magnetic rotation of hemozoin crystals in water and blood.

Figure 7

(a)/(b) MLD amplitude/phase for hemozoin in water over a limited frequency range optimal in sense of signal to noise ratio. (c)/(d) MLD amplitude/phase for hemozoin in blood over the same frequency range. The concentration of hemozoin varies over five and three orders of magnitude in water and blood, respectively. The amplitude of the MLD signal is normalized to 1 ng/μl hemozoin content. Concentrations of blood samples refer to the hemozoin contents in full blood and not in hemolyzed blood. The concentration levels of 0.5 pg/μl and 15 pg/μl are still readily detectable in water and blood, respectively. Inset in panel (c) shows the reproducibility for the baseline (black curves) and the lowest-concentration data (with color coding used in the main panel).