TABLE 1.
DBC Treatment | Gavage | Pill |
---|---|---|
Body Weight | Mean Body Weight (g) ± SD | Mean Body Weight (g) ± SD |
After 5 days of Dosing | ||
Control | 27.8 ±1.3 | 25.4 ±1.1 |
0.1mg/kg | 28.9 ±1.4 | |
lmg/kg | 29.8 ±1.2 | 25.9 ±1.8 |
10mg/kg | 26.7 ±1.7 | 24.7 ±1.4 |
100mg/kg | 22.8* ±2.8 | |
Persistence (+ 4 week hold) | ||
Control | 30.4±1.4 | 27.0 ±2.1 |
lmg/kg | 29.9 ±2.3 | |
10mg/kg | 28.1±1.8 | 29.6 ±3.2 |
Cell Recovery | Cells × 106 /mg spleen ± SD | Cells × 106 /mg spleen ± SD |
After 5 days of Dosing | ||
Control | 1.3 ±0.2 | 1.9 ±0.4 |
0.1mg/kg | 1.5 ±0.4 | |
1mg/kg | 1.3 ±0.3 | 1.9 ±0.4 |
10mg/kg | 1.3 ±0.4 | 1.7 ±0.5 |
100mg/kg | 1.1 ±0.7 | |
Weights after 4 week hold | ||
Control | 1.6 ±0.2 | 1.4 ±0.2 |
1mg/kg | 1.5 ±0.4 | |
10mg/kg | 1.6 ±0.4 | 1.6 ±0.3 |
Significantly different from Control p ≤ .05 ANOVA followed by Dunnett's t-test.