Table 1.
Comparison of time-intensity curves of targeted and non-targeted contrast ultrasound imaging
| Echo mean (dB) | Peak intensity (dB) | Wash-in time (s) | Time to peak (s) | Time from peak to one-half (s) | ||
|---|---|---|---|---|---|---|
| Non-targeted UCA (N = 22) | Lumen | 4.4 ± 1.9 | 12.3 ± 4.9 | 3.5 ± 2.3 | 15.3 ± 3.9 | 29.7 ± 6.3 |
| Intima | 3.5 ± 1.6 | 12.7 ± 5.6 | 6.1 ± 2.2 | 18.2 ± 4.0 | 35.0 ± 5.9 | |
| Intima/lumen ratio | 0.79 ± 0.21 | 1.01 ± 0.23 | 1.4 ± 0.55 | 1.15 ± 0.45 | 1.18 ± 0.48 | |
| Plaque | 4.2 ± 2.1 | 15.4 ± 5.4 | 7.2 ± 2.4 | 18.5 ± 4.3 | 38.5 ± 5.6 | |
| Plaque/lumen ratio | 0.95 ± 0.23 | 1.23 ± 0.34 | 1.98 ± 0.55 | 1.2 ± 0.53 | 1.29 ± 0.49 | |
| Targeted UCA (N = 24) | Lumen | 4.6 ± 2.5 | 12.5 ± 6.7 | 3.7 ± 2.9 | 15.9 ± 4.9 | 30.2 ± 6.8 |
| Intima | 5.5 ± 1.6* | 16.3 ± 7.2* | 5.5 ± 2.6 | 18.2 ± 5.2 | 43.8 ± 7.8* | |
| Intima/lumen ratio | 1.20 ± 0.28* | 1.31 ± 0.33* | 1.4 ± 0.48 | 1.14 ± 0.51 | 1.41 ± 0.53* | |
| Plaque | 6.8 ± 1.8* | 18.7 ± 5.9* | 6.9 ± 2.8 | 20.5 ± 5.6 | 46.7 ± 7.9* | |
| Plaque/lumen ratio | 1.47 ± 0.36* | 1.50 ± 0.37* | 1.9 ± 0.49 | 1.2 ± 0.57 | 1.53 ± 0.47* | |
UCA ultrasound contrast agent
*Significant difference between targeted and non-targeted UCA (P < 0.05). Values are provided as the mean ± SD