. Author manuscript; available in PMC: 2013 Mar 12.

Published in final edited form as: Transplantation. 2010 Dec 27;90(12):1401–1408. doi: 10.1097/TP.0b013e3182000085

Table 3A.

Multivariate model results with top 15 SNPs (ranked by p-value) associated with time to acute rejection, stratified by transplant center. Model also adjusted for recipient factors (race, age, gender, weight), PRA presence, number of HLA mismatches, T or B-cell cross-match positive, antibody induction, type of calcineurin inhibitor used, steroid use at day 14 post-transplant, simultaneous kidney-pancreas transplant (versus kidney transplant alone), cause of ESRD, living donor (versus deceased donor) and donor age. All variant data from dbSNP Build 131

SNP	Gene	Variant	HR^#	95% C.I.	p-value	Minor Allele in AA^*	MAF⁺ in AA	Minor Allele in Non-AA	MAF⁺ in non-AA
rs2227931	ATR	coding-synon	1.51	[1.20–1.90]	4.09E-04	C	0.19	C	0.38
rs2267130^*	CHEK2	Intron	0.67	[0.53–0.84]	5.84E-04	C	0.09	C	0.46
rs4839469^*	VANGL1	Missense	1.62	[1.23–2.13]	6.10E-04	A	0.07	A	0.14
rs3088142	DUSP13	Missense	1.43	[1.15–1.78]	1.17E-03	C	0.29	T	0.44
rs2229032	ATR	Missense	0.55	[0.38–0.80]	1.75E-03	A	0.09	A	0.16
rs2228224^*	GLI1	Missense	0.69	[0.54–0.88]	2.45E-03	A	0.23	G	0.41
rs2227929^*	ATR	coding-synon	1.43	[1.13–1.80]	2.74E-03	C	0.19	C	0.38
rs3783408	MAP4K5	nearGene-5	1.47	[1.13–1.90]	3.49E-03	A	0.08	A	0.26
rs4348159^*	UGT2B7	coding-synon	0.47	[0.28–0.78]	3.62E-03	T	0.28	T	0.09
rs4253199	ERCC6	Missense	3.77	[1.54–9.26]	3.76E-03	T	0.06	0	0
rs6163	CYP17A1	coding-synon	0.72	[0.57–0.90]	3.76E-03	A	0.38	A	0.42
rs743572	CYP17A1	coding-synon	0.72	[0.57–0.90]	3.80E-03	G	0.38	G	0.42
rs2072651	TPP1	Intron	1.49	[1.13–1.96]	4.50E-03	T	0.2	T	0.17
rs3125001	NOTCH1	Intron	0.65	[0.48–0.88]	4.75E-03	C	0.33	T	0.39
rs3093816	CCNH	Intron	1.38	[1.10–1.72]	4.84E-03	C	0.25	C	0.41

(Abbreviations: AA= African Americans, MAF= Minor Allele Frequency, synon=synonymous, untranslated-5= variant in the untranslated 5′ end of gene, near-gene-5= variation within 2000 bases of 5′ end of gene)

Analysis conducted using a Cox proportional hazards model.

Same SNPs seen in the top 15 SNPs associated with cellular acute rejection.

^**

There was some linkage disequilibrium (LD) between the two SNPs in CYP17A1, with r²= 1.00 in non-African Americans and African Americans, separately. There was also some LD between the two SNPs in ATR, with r² >0.95 The remaining SNPs in the table had an r² < 0.2.