Table 1.

Lopinavir and ritonavir pharmacokinetic parameters across the three study regimens

Pharmacokinetic parameter	Regimen	CV%	GM	90% CI		GMR	90% CI
Lopinavir
AUC0–12 (ng h/mL)	1	35	99599	87180	113787
	2	46	73603	65121	83191	0.74	0.65	0.84
	3	34	45146	39251	51927	0.45	0.40	0.51
Ctrough (ng/mL)	1	46	5776	4884	6831
	2	54	4293	3603	5115	0.74	0.62	0.89
	3	50	1749	1419	2156	0.30	0.25	0.36
Cmax (ng/mL)	1	37	11965	10400	13766
	2	50	8939	8047	9930	0.75	0.66	0.85
	3	29	6404	5648	7262	0.54	0.47	0.61
Ritonavir
AUC0–12 (ng h/mL)	1	41	4644	3808	5664
	2	50	10462	8972	12200	2.25	1.96	2.59
	3	48	1625	1390	1899	0.35	0.30	0.40
Ctrough (ng/mL)	1	66	154	126	189
	2	74	297	236	374	1.93	1.64	2.26
	3	65	56	45	69	0.36	0.31	0.42
Cmax (ng/mL)	1	46	887	708	1111
	2	42	1963	1654	2330	2.21	1.85	2.65
	3	50	273	228	325	0.31	0.26	0.37

GMRs are calculated using 400/100 mg of lopinavir/ritonavir twice daily (Regimen 1) as the referent group.