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. 2013 Mar 12;7:17. doi: 10.3389/fnbeh.2013.00017

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Copyright © 2013 Kobayashi, Sano, Vannoni, Goto, Suzuki, Oba, Kawasaki, Kanba, Lipp, Murphy, Wolfer and Itohara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Learning and memory in mHb:DTA mice. (A–C) Spatial learning and memory in the Morris water maze (mice were 7–8 months-old, n = 12/group). (A) There were no differences between genotypes in the acquisition rates, swim distances (A), or escape latency (B). (C) Probe tests revealed significant quadrant preference for the controls [F_{(3, 44)} = 8.5] but not mHb:DTA mice [F_{(3, 44)} = 1.5]. T, O, L, and R represent target, opposite, left and right quadrants, respectively. (D) There were no differences between genotypes in freezing rates during conditioning or contextual- and cue-dependent memory tests (mice were 6–7 months old, n = 12/group). (E,F) Radial maze test. Number of revisit errors (E) and arms chosen during the first 8 visits (F) (mice were 3–4 months old; n = 12/group). Statistical analyses were performed for data from days 8 to 14, F_{(1, 22)} = 10.1 (E) and 13.4 (F). Data represent mean ± SEM.