Table 1.
Levels of monoamines and metabolites in selected brain regions.
| Region | Genotype | NA | MHPG | DA | DOPAC | HVA | 5-HT | 5-HIAA |
|---|---|---|---|---|---|---|---|---|
| IPN | Control | 4043 ± 109 | n.d. | 1738 ± 239 | 1654 ± 211 | 2111 ± 115 | 3561 ± 214 | 6589 ± 429 |
| mHb:DTA | 5169 ± 384 | n.d. | 2513 ± 331 | 2182 ± 300 | 2424 ± 212 | 3829 ± 150 | 7014 ± 410 | |
| p value | 0.030 | 0.101 | 0.205 | 0.263 | 0.312 | 0.494 | ||
| Raphe | Control | 8664 ± 579 | n.d. | 1540 ± 178 | 652 ± 84 | 1283 ± 93 | 9864 ± 438 | 9342 ± 526 |
| mHb:DTA | 8923 ± 584 | n.d. | 1513 ± 158 | 599 ± 39 | 1224 ± 60 | 10,121 ± 399 | 9685 ± 378 | |
| p value | 0.763 | 0.913 | 0.548 | 0.589 | 0.674 | 0.595 | ||
| VTA | Control | 4976 ± 329 | n.d. | 4305 ± 657 | 3200 ± 322 | 3334 ± 203 | 4477 ± 515 | 7501 ± 308 |
| mHb:DTA | 4701 ± 265 | n.d. | 3546 ± 441 | 2975 ± 237 | 3223 ± 214 | 3947 ± 368 | 7615 ± 366 | |
| p value | 0.523 | 0.338 | 0.575 | 0.720 | 0.405 | 0.825 | ||
| mPFC | Control | 2980 ± 289 | ND | 191 ± 25 | 318 ± 43 | 791 ± 46 | 1096 ± 106 | 2729 ± 127 |
| mHb:DTA | 2792 ± 71 | ND | 200 ± 23 | 280 ± 10 | 728 ± 47 | 1102 ± 34 | 2547 ± 69 | |
| p value | 0.511 | 0.785 | 0.376 | 0.358 | 0.953 | 0.213 | ||
| Striatum | Control | ND | 2273 ± 336 | 66,198 ± 5503 | 14,616 ± 1356 | 9707 ± 840 | 1638 ± 135 | 1852 ± 163 |
| mHb:DTA | ND | 2568 ± 278 | 69,070 ± 6685 | 13,244 ± 1201 | 9671 ± 704 | 1627 ± 140 | 1833 ± 165 | |
| p value | 0.509 | 0.745 | 0.461 | 0.975 | 0.958 | 0.937 |
Data are shown as mean ± SEM (pg/mg protein). Two tailed T-test for statistics. n.d., not detected; ND, not determined; 5-HT, 5-hydroxytryptamine; 5-HIAA, 5-hydroxyindoleacetic acid; NA, noradrenaline; MHPG, 3-methoxy-4-hydroxy-phenylglycol; DA, dopamine; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid).