Figure 2.

Human FII-specific antibody titers in pre- and posttreatment samples from wild-type and transgenic animals from line E (a) and line H (b), measured by ELISA and expressed as optical density (OD). Results were obtained from the screening assay where all samples were diluted 1:100. One transgenic male mouse from line E died during the study. Mean OD values are indicated by horizontal bars. Cut-off value was calculated to 0.438, values above this cutoff point were regarded as positive. Wt, wild type; Tg, transgenic.