Table 1.
Statistical Comparison of the Specific Antibody Response Between Samples from Wild-Type (Wt) and Transgenic (Tg) Mice Before and After Treatment with a Combination of Recombinant Human FII, FVII, and FX
| FII | FVII | FX | |||||
|---|---|---|---|---|---|---|---|
| Line E | Line H | Line E | Line H | Line E | Line H | ||
| Wt | Male | <0.0001 | <0.0001 | 0.0001 | <0.0001 | 0.06 | 0.04 |
| Female | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.001 | <0.0001 | |
| Tg | Male | 0.06 | 0.32 | 0.04 | 0.07 | 0.20 | 0.003 |
| Female | 0.03 | 0.13 | 0.13 | 0.0001 | 0.01 | 0.04 | |
Differences between pre- and postdose samples were analyzed using OD values and a Paired t-test. A value of p < 0.05 was considered to be statistically significant, marked with bold.