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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Radiat Res. 2012 Feb 21;177(4):508–513. doi: 10.1667/rr2918.1

FIG. 2.

FIG. 2

Imaging caspase activation during radiotherapy of cancer. Caspase 3 activation in 4T1 tumors as detected by a caspase 3 reporter. Left panels depict the structure of a proteasome-based caspase 3 reporter (top left) and its principle of action (lower left). Right panels showed caspase 3 activities in 4T1 tumors transduced with the control, as well as caspase reporter genes. The difference between the control and caspase 3 reporter groups are significant at days 3, 5, and 7 (P < 0.01, n = 5, t test). Error bars, SEM.