Table 1.
Nominally significant associations of SNPs with baseline exercise test duration in Blacks.
| Blacks | Mean (SE) Baseline duration (min) by genotype | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| GENE | SNP | p-value | R2 | Common allele homozygote |
N | Heterozygote/ or minor allele carrier |
N | Minor allele homozygote |
N |
| AGT | rs11568045 | 0.0454 | 0.001 | 8.7 (0.3) | 1240 | 8.4 (0.3) | 485 | 8.8 (0.4) | 49 |
| ATP1A2 | rs9660705 | 0.0148 | 0.002 | 8.6 (0.3) | 1391 | 8.6 (0.3) | 182 | 7.0 (0.7) | 9 |
| TTN | rs6732060 | 0.0146 | 0.002 | 8.7 (0.3) | 1053 | 8.5 (0.3) | 622 | 9.0 (0.4) | 65 |
| rs2366753 | 0.0147 | 0.002 | 8.7 (0.3) | 923 | 8.6 (0.3) | 723 | 9.0 (0.3) | 126 | |
| rs2627038 | 0.0222 | 0.002 | 8.7 (0.3) | 483 | 8.6 (0.3) | 859 | 8.9 (0.3) | 392 | |
| PPARGC1A | rs2932971 | 0.0198 | 0.002 | 8.6 (0.3) | 1064 | 8.7 (0.3) | 604 | 8.1 (0.3) | 88 |
| rs7657517 | 0.0363 | 0.001 | 8.5 (0.3) | 493 | 8.7 (0.3) | 846 | 8.8 (0.3) | 431 | |
| NOS3 | rs1799983 | 0.0015 | 0.003 | 8.5 (0.3) | 1424 | 8.9 (0.3) | 334 | 8.3 (0.5) | 23 |
| rs3918196* | 0.0039 | 0.002 | 8.5 (0.3) | 1576 | 8.9 (0.3) | 167 | --- | --- | |
| ACTN3 | rs2275998 | 0.0275 | 0.002 | 8.7 (0.3) | 871 | 8.4 (0.3) | 764 | 8.5 (0.3) | 141 |
| HIF1A | rs1957755 | 0.0228 | 0.002 | 8.6 (0.3) | 1518 | 8.8 (0.3) | 214 | 9.6 (0.6) | 12 |
| ACE | rs4316 | 0.0483 | 0.001 | 8.4 (0.3) | 656 | 8.6 (0.3) | 824 | 8.7 (0.3) | 289 |
*
genotypes grouped by minor allele carrier status