Table 5.
Nominally significant associations of SNPs with decrease in exercise test duration over 20 years by genotype in Whites.
| Whites | Mean (SE) decrease in duration (min.) by genotype | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| GENE | SNP | p-value | R2 | Common allele homozygote |
N | Heterozygote/ or minor allele carrier |
N | Minor allele homozygote |
N |
| AGT | rs5051 | 0.0229 | 0.003 | −3.5 (0.1) | 444 | −3.5 (0.1) | 618 | −3.2 (0.1) | 238 |
| AMPD1 | rs2010899 | 0.0323 | 0.003 | −3.6 (0.1) | 396 | −3.5 (0.1) | 575 | −3.3 (0.1) | 259 |
| PPARGC1A | rs768695 | 0.0003 | 0.007 | −3.6 (0.1) | 335 | −3.3 (0.1) | 590 | −3.6 (0.1) | 321 |
| rs3774921 | 0.0442 | 0.003 | −3.6 (0.1) | 362 | −3.4 (0.1) | 560 | −3.7 (0.1) | 294 | |
| rs7657517 | 0.0071 | 0.004 | −3.6 (0.1) | 939 | −3.3 (0.1) | 276 | −4.0 (0.3) | 27 | |
| rs4452416 | 0.0134 | 0.003 | −3.4 (0.1) | 944 | −3.7 (0.1) | 316 | −3.7 (0.3) | 19 | |
| rs7677000 | 0.0067 | 0.004 | −3.6 (0.1) | 875 | −3.3 (0.1) | 314 | −3.9 (0.2) | 38 | |
| ANG | rs4470055 | 0.0037 | 0.005 | −3.5 (0.1) | 679 | −3.4 (0.1) | 483 | −3.9 (0.2) | 85 |
| rs1010458 | 0.0245 | 0.003 | −3.5 (0.1) | 812 | −3.5 (0.1) | 363 | −4.0 (0.2) | 52 | |