. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: Genes Immun. 2012 Nov 15;14(1):13–18. doi: 10.1038/gene.2012.48

Table 4.

SNP–SNP interaction and sarcoidosis risk: ORs at ANXA11 rs1049550 stratified by HLA–DRA rs9268839^a genotype and ethnicity

	HLA–DRA rs9268839 genotype						P-value for SNP–SNP^c
	AA		AG		GG
	N^b	OR (95% CI)	N^b	OR (95% CI)	N^b	OR (95% CI)
ANXA11 rs1049550 genotype
African American
TT	571/321	1 (ref)	294/235	1 (ref)	20/37	1 (ref)	0.004
TC	191/149	0.70 (0.54–0.90)	109/116	0.77 (0.56–1.05)	15/13	3.12 (1.07–9.04)
CC	13/13	0.54 (0.25–1.15)	16/7	2.05 (0.79–5.31)	3/2	7.21 (0.51–103.08)
European American
TT	83/27	1 (ref)	91/68	1 (ref)	15/20	1 (ref)	0.001
TC	71/43	0.54 (0.30–0.97)	103/100	0.77 (0.50–1.17)	20/30	0.91 (0.37–2.23)
CC	23/32	0.23 (0.12–0.47)	31/24	0.97 (0.52–1.81)	9/6	1.87 (0.53–6.65)

Abbreviations: ANXA11, annexin A11; CI, confidence interval; HLA, human leukocyte antigen; OR, odds ratio; SNP, single-nucleotide polymorphism.

SNP rs9268839, located ~16 kb downstream of HLA–DRA, is univariately associated with risk of sarcoidosis in both African Americans (OR = 0.71; 95% CI = 0.61–0.83; P = 9.8*10⁻⁶) and European Americans (OR = 0.67; 95% CI = 0.54–0.84; P = 3.7*10⁻⁴).

N corresponds to the number of case/control individuals for each genotype by ethnicity.

P-value for the interaction corresponds to the Wald test of the multiplicative interaction term (additive model) from the standard unconditional logistic regression model fit using generalized estimating equations.