Figure 2. Temporal and spatial immune features of the conventionalized in contrast to conventionally raised mice. Ingenuity biological processes that were significantly modulated in the gut tissue of conventionalized mice as well as conventionally raised mice compared with the germfree control. Significance was calculated via a one-tailed Fisher’s Exact test in IPA and is represented as –log (p value); -log values exceeding 1.30 were significant p < 0.05, (n = 4−5 mice/time point).