Figure 2. Screening of lactobacilli for anti-IP-10 activity. Human fecal L.casei isolates (L.c BFLM14, L.c BFLM 100, L.c BFLM 218) and commercial strains (L.c shirota, L.c defensis) were screened for their ability to degrade murine IP-10. All tested strains secrete low amounts of IP-10-degrading prtP-encoded lactocepin compared with L.p. The anti-IP-10 activity was strongly increased after cultivation in higher cell densities (1x = 5x10⁷ cfu/ml, 10x = 5x10⁸ cfu/ml). L.c BFLM 218 prtP^dis served as negative control.