Table 2.
Differentially expressed genes in PC-treated hTERT-OA 13A FLS compared to the untreated cells.
| Biological process | Gene name | Gene ID | Differ. Expre. (fold)* |
Description |
|---|---|---|---|---|
| Muscle tissue development | IGFBP5 | AW157548 | 8.57 | Insulin-like growth factor binding protein 5 |
| CACNB4 | NM_000726 | 2.73 | Calcium channel, voltage-dependent, beta-4-subunit | |
| TPM1 | AI521618 | 2.43 | Tropomyosin 1 (alpha) | |
| JAG1 | U61276 | 2.02 | Jagged 1 (Alagille syndrome) | |
| MORF4L2 | H43976 | 1.90 | Mortality factor 4 like 2 | |
| NRG1 | NM_013957 | 1.88 | Neuregulin 1 | |
| SIRT2 | BG722779 | 1.86 | Sirtuin (silent mating type information regulation 2 homolog) 2 | |
| NF1 | D12625 | 1.80 | Neurofibromin 1 | |
| OBSL1 | BF446688 | 1.78 | Obscurin-like 1 | |
| MBNL1 | AA732240 | 1.73 | Muscleblind-like (Drosophila) | |
| TPM1 | NM_000366 | 1.72 | Tropomyosin 1 (alpha) | |
| CAV2 | AA150110 | 1.67 | Caveolin 2 | |
| RXRA | BE675800 | 1.66 | Retinoid X receptor, alpha | |
| NR2F2 | AL554245 | 1.63 | Nuclear receptor subfamily 2, group F, member 2 | |
| TCF7L2 | AV721430 | 1.61 | Transcription factor 7-like 2 (T-cell specific, HMG-box) | |
| TBX2 | U28049 | −4.17 | T-box 2 | |
| ADRB2 | NM_000024 | −2.36 | Adrenergic, beta-2-receptor, surface | |
| SORT1 | BE742268 | −1.93 | Sortilin 1 | |
| GJC1 | NM_005497 | −1.77 | Gap junction protein, gamma 1, 45 kDa | |
| CENPF | U30872 | −1.77 | Centromere protein F, 350/400 ka (mitosin) | |
| BCL2 | NM_000657 | −1.71 | B-cell CLL/lymphoma 2 | |
| TBX3 | U69556 | −1.71 | T-box 3 | |
| SDC1 | NM_002997 | −1.65 | Syndecan 1 | |
| TBX5 | AW269421 | −1.54 | T-box 5 | |
| RARB | NM_015854 | −1.51 | Retinoic acid receptor, beta | |
|
| ||||
| Skeletal development | ANXA2 | D28364 | 2.17 | Annexin A2 |
| VDR | AA772285 | 2.11 | Vitamin D (1,25-dihydroxyvitamin D3) receptor | |
| GNAS | AI693143 | 1.95 | GNAS complex locus | |
| ACAN | NM_001135 | 1.80 | Aggrecan | |
| COL1A1 | AI743621 | 1.66 | Collagen, type I, alpha-1 | |
| COL1A2 | AA628535 | 1.88 | Collagen, type I, alpha-2 | |
| COL11A1 | NM_001854 | 1.50 | Collagen, type XI, alpha-1 | |
| COL12A1 | AU146651 | 1.93 | Collagen, type XII, alpha-1 | |
| MSX2 | D89377 | 1.85 | Msh homeobox 2 | |
| GHR | NM_000163 | 1.76 | Growth hormone receptor | |
| MEF2C | AL536517 | 1.59 | Myocyte enhancer factor 2C | |
| THRA | NM_003250 | 1.57 | Thyroid hormone receptor, alpha | |
| RUNX2 | AW469546 | 1.55 | Runt-related transcription factor 2 | |
| CLEC3B | NM_003278 | 1.55 | Exosome component 7 | |
| MEF2C | N22468 | 1.55 | Myocyte enhancer factor 2C | |
| IGFBP4 | NM_001552 | 1.54 | Insulin-like growth factor binding protein 4 | |
| PRKRA | AA279462 | 1.53 | Protein kinase, interferon-inducible RNA-dependent activator | |
| TNFRSF11B | NM_002546 | 1.50 | Tumor necrosis factor receptor superfamily, member 11b | |
| BMPR1B | AA935461 | −2.12 | Bone morphogenetic protein receptor, type IB | |
| ANKH | AF274753 | −1.93 | Ankylosis, progressive homolog (mouse) | |
| ACVR2A | NM_001616 | −1.89 | Activin A receptor, type IIA | |
| CYTL1 | NM_018659 | −1.83 | Cytokine-like 1 | |
| TBX3 | U69556 | −1.71 | T-box 3 (ulnar mammary syndrome) | |
| SOX9 | NM_000346 | −1.71 | SRY- (sex-determining-region-Y-) box 9 | |
| FOXC2 | NM_005251 | −1.68 | Forkhead box C2 (MFH-1, mesenchyme forkhead 1) | |
| KIAA1217 | BC017424 | −1.66 | KIAA1217 | |
| MMP9 | NM_004994 | −1.61 | Matrix metallopeptidase 9 | |
| TGFBR2 | NM_003242 | −1.51 | Transforming growth factor, beta-receptor II (70/80 kDa) | |
|
| ||||
| Collagen biosynthetic process | COL3A1 | AU146808 | 1.83 | Collagen, type III, alpha-1 |
| COL1A2 | AA628535 | 1.88 | Collagen, type I, alpha-2 | |
| COL1A1 | AI743621 | 1.66 | Collagen, type I, alpha-1 | |
| TRAM2 | AI986461 | 1.58 | Translocation-associated membrane protein 2 | |
| ITGA2 | N95414 | −1.74 | Integrin, alpha-2 (CD49B, alpha-2 subunit of VLA-2 receptor) | |
|
| ||||
| Collagen catabolic process | MMP3 | NM_002422 | 3.18 | Matrix metallopeptidase 3 (stromelysin 1, progelatinase) |
| ADAMTS5 | BI254089 | 3.32 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | |
| ADAMTS14 | W60649 | 2.15 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | |
| MMP16 | U79292 | 1.80 | Matrix metallopeptidase 16 (membrane inserted) | |
| MMP9 | NM_004994 | −1.61 | Matrix metallopeptidase 9 | |
*Negative number indicates decreased expression (fold) in PC-treated hTERT-OA 13A FLS compared with the untreated cells. Positive number indicates elevated expression (fold) in PC-treated hTERT-OA 13A FLS compared with the untreated cells.