Table 2.
Predictors of Cardiac Death in Patients With HIV Cardiomyopathy
| Variable | HR | 95% CI | p Value |
|---|---|---|---|
| Clinical variables | |||
| Age, per yr | 0.99 | 0.93–1.06 | 0.79 |
| Hypertension, yes vs. no | 0.68 | 0.20–2.22 | 0.52 |
| Diabetes mellitus, yes vs. no | 0.83 | 0.18–3.85 | 0.81 |
| Dyslipidemia, yes vs. no | 0.64 | 0.17–2.41 | 0.51 |
| NYHA functional class IV vs. classes I to III | 7.20 | 2.20–23.65 | 0.007 |
| Hemodynamic variables | |||
| Resting SBP, per mm Hg | 1.01 | 0.97–1.06 | 0.56 |
| Resting DBP, per mm Hg | 1.01 | 0.95–1.07 | 0.76 |
| Echocardiographic variables | |||
| LADI, per cm/m2 | 2.63 | 0.56–12.27 | 0.22 |
| LVESVI, per ml/m2 | 1.02 | 0.99–1.05 | 0.16 |
| LVEDVI, per ml/m2 | 1.02 | 0.99–1.06 | 0.15 |
| LVEF, per percentage | 0.96 | 0.91–1.01 | 0.17 |
| Rest LV WMSI, per U | 1.46 | 0.53–4.06 | 0.46 |
| Rest RV WMSI, per U | 1.35 | 0.68–2.66 | 0.39 |
| ICR, absent vs. present | 6.60 | 1.93–22.62 | 0.003 |
| HIV-associated factors | |||
| CD4 count, per cell/mm3 | 1.00 | 0.99–1.00 | 0.90 |
| Viral load, per copy/ml | 1.00 | 1.00–1.00 | 0.87 |
| Duration of HIV infection, per year | 0.99 | 0.89–1.11 | 0.90 |
Values were generated using a univariable Cox proportional hazard analysis. Values in bold indicate statistical significance. A p value <0.05 is considered significant.
CI = confidence interval; HR = hazard ratio; ICR = inotropic contractile reserve; LADI = left atrial dimension index; other abbreviations as in Table 1.