Table 4.
Univariate and multivariate regression analysis in subjects with and without major bleeding in overall population
| Bleeding (n=165) | No Bleeding (n=2917) | Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|---|
|
| ||||||
| Odds Ratio (95% CI) | P value | Odds Ratio (95% CI) | P value | |||
| Mean Age (yr) | 61.5 (± 15.5) | 60.7 (± 13.2) | 1.00 [0.99–1.02] | 0.49 | ||
| Female | 114 (69.1) | 1708 (58.6) | 1.58 [1.13–2.24] | 0.01 | 2.34 [1.63–3.41] | <0.001 |
| Race | 0.02 | 0.15 | ||||
| White | 122 (73.9) | 1883 (64.6) | 0.89 [0.53–1.62] | 1.10 [0.63–2.07] | ||
| Black | 14 (8.5) | 425 (14.6) | 0.45 [0.21–0.96] | 0.68 [0.31–1.49] | ||
| Hispanic | 14 (8.5) | 402 (13.8) | 0.48 [0.23–1.02] | 0.65 [0.29–1.43] | ||
| Other (reference level) | 15 (9.1) | 207 (7.1) | 1 | 1 | ||
| Admission Type | <0.001 | 0.48 | ||||
| Elective (reference level) | 140 (84.9) | 2761 (94.7) | 1 | 1 | ||
| Emergency or Urgent Surgery | 25 (15.2) | 156 (5.3) | 3.16 [1.97–4.90] | 1.23 [0.68–2.11] | ||
| Procedure | <0.001 | <0.001 | ||||
| Spine (reference level) | 110 (66.7) | 1051 (36.0) | 1 | 1 | ||
| Knee | 19 (11.5) | 982 (33.7) | 0.18 [0.11–0.30] | 0.19 [0.11–0.31] | ||
| Hip | 36 (21.8) | 884 (30.3) | 0.39 [0.26–0.57] | 0.35 [0.23–0.52] | ||
| CAD | 33 (20.0) | 294 (10.1) | 2.23 [1.47–3.29] | <0.001 | 2.49 [1. 58–3.85] | <0.001 |
| Hypertension | 80 (48.5) | 1433 (49.1) | 0.97 [0.71–1.33] | 0.87 | ||
| Cancer | 21 (12.7) | 48 (1.7) | 8.72 [4.99–14.76] | <0.001 | 6.85 [3.57–12.84] | <0.001 |
| Diabetes Mellitus | 28 (17.0) | 419 (14.4) | 1.22 [0.79–1.82] | 0.36 | ||
| COPD | 10 (6.1) | 59 (2.0) | 3.13 [1.48–5.96] | 0.001 | 2.69 [1.21–5.42] | 0.01 |
| CKD | 9 (5.5) | 73 (2.5) | 2.25 [1.03–4.35] | 0.03 | 1.53 [0.65–3.24] | 0.30 |
| PVD | 5 (3.0) | 18 (0.6) | 5.03 [1.65–12.80] | 0.002 | 2.63 [0.81–7.25] | 0.08 |
CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; CKD, chronic kidney disease; PVD, peripheral vascular disease