Figure 2. Panitumumab-IRDye versus aspecific control (IgG-IRDye).
(A) Uptake of the near-infrared (NIR) fluorescence agent panitumumab-IRDye800 versus aspecific IgG-IRDye detected with the Pearl and SPY Systems in mice with flank SCC1 tumors. (B) The tumor-to-background is significantly higher versus the control for both the Pearl and SPY. (C) Panitumumab-IRDye demonstrates significantly greater fluorescence in a tumor versus the split-thickness skin graft for both the Pearl and SPY imager. Error bars indicate the SD.