Fig. 8.
Progressive fat accumulation and adipocyte hypertrophy in AQP7 deficiency. (a) (top) Photographs of mice showing increased gonadal fat in AQP7 null mice at age 16 weeks (white arrows). (bottom) Histology of gonadal fat (stained with hematoxylin and eosin). Bar, 100μm. (b) Age-dependent epididymal fat mass (S.E., six mice per group). (c) Glycerol and triglyceride content in adipocytes from mice of age 16 weeks (S.E., *P < 0.01). (d) Proposed mechanism for adipocyte hypertrophy in AQP7 deficiency. See text for explanations. From Hara-Chikuma et al. (2005)