Table 1. Baseline characteristics of study participants grouped by thyroid status.
| Thyroid status | p-value for difference | ||||
| Subclinical hyperthyroidism N = 65 | Euthyroidism N = 4,928 | Subclinical hypothyroidism N = 161 | Subclinical hyperthyroidism vs. euthyroidism | Subclinical hypothyroidism vs. euthyroidism | |
| Demographics | |||||
| Female, n (%) | 48 (73.8%) | 2,394 (48.6%) | 103 (64.0%) | <0.001 | <0.001 |
| Age (years), mean (se) | 75.33 (0.38) | 75.28 (0.05) | 75.63 (0.25) | 0.90 | 0.20 |
| Education (years), mean (se) | 15.29 (0.27) | 15.14 (0.03) | 15.17 (0.17) | 0.56 | 0.89 |
| Barthel score, mean (se)* | 19.63 (0.09) | 19.78 (0.01) | 19.86 (0.06) | 0.08 | 0.18 |
| IADL score, mean (se) * | 13.59 (0.12) | 13.65 (0.01) | 13.64 (0.08) | 0.62 | 0.95 |
| Biometrics, mean (se)* | |||||
| Weight (kg) | 71.73 (1.51) | 73.47 (0.17) | 74.76 (0.96) | 0.25 | 0.19 |
| Height (cm) | 166.60 (0.83) | 165.43 (0.10) | 166.58 (0.52) | 0.15 | 0.03 |
| BMI (kg/m2) | 25.69 (0.51) | 26.81 (0.06) | 26.88 (0.33) | 0.03 | 0.83 |
| SBP (mmHg) | 153.79 (2.70) | 154.60 (0.31) | 156.77 (0.72) | 0.77 | 0.21 |
| DBP (mmHg) | 82.60 (1.42) | 83.86 (0.16) | 84.50 (0.90) | 0.38 | 0.49 |
| Risk factors, n (%) | |||||
| Current smoker | 12 (18.5%) | 1,367 (27.7%) | 36 (22.4%) | 0.10 | 0.13 |
| History of diabetes | 10 (15.4%) | 525 (10.7%) | 23 (14.3%) | 0.22 | 0.14 |
| History of hypertension | 38 (58.5%) | 3,008 (61.0%) | 112 (69.6%) | 0.67 | 0.03 |
| History of vascular disease | 25 (40.0%) | 2177 (44.2%) | 67 (41.6%) | 0.50 | 0.52 |
| History of TIA/stroke | 6 (9.2%) | 552 (11.2%) | 20 (12.4%) | 0.62 | 0.63 |
| Lipid profile, mean (se)* | |||||
| HDL cholesterol (mmol/L) | 1.24 (0.04) | 1.28 (0.01) | 1.27 (0.03) | 0.32 | 0.62 |
| LDL cholesterol (mmol/L) | 3.82 (0.10) | 3.78 (0.01) | 3.86 (0.06) | 0.69 | 0.20 |
| Total cholesterol (mmol/L) | 5.70 (0.11) | 5.67 (0.01) | 5.77 (0.07) | 0.80 | 0.14 |
| Triglycerids (mmol/L) | 1.57 (0.09) | 1.54 (0.01) | 1.56 (0.05) | 0.74 | 0.78 |
Abbreviations: n, number; se, standard error; IADL, Instrumental Activities of Daily Living; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TIA, transient ischemic attack; HDL, high density cholesterol lipoprotein; LDL, low density cholesterol lipoprotein.
*
= adjusted for sex and age at baseline, assessed by linear regression.