Table 3. Association of thyroid status with cognitive performance during follow-up.

	Annual change in cognitive test score		Additional change
Cognitive test	All participants		Subclinical hyperthyroidism vs. euthyroidism		Subclinical hypothyroidism vs. euthyroidism
	Est (se)	p-value	Est (se)	p-value	Est (se)	p-value
MMSE, score	0.01 (0.01)	0.31	−0.03 (0.06)	0.61	0.08 (0.04)	0.03
Stroop, seconds	0.68 (0.07)	<0.001	−0.48 (0.64)	0.45	0.70 (0.41)	0.09
LDCT, digits coded	−0.35 (0.02)	<0.001	−0.10 (0.14)	0.45	−0.02 (0.09)	0.85
PLTi, pictures remembered	−0.02 (0.01)	<0.001	−0.07 (0.06)	0.23	0.03 (0.04)	0.46
PLTd, pictures remembered	−0.07 (0.01)	<0.001	−0.13 (0.08)	0.13	0.00 (0.05)	0.94

Abbreviations: Est, estimates; se, standard error; MMSE, Mini-Mental State Examination; LDCT, Letter-Digit Coding Test; PLTi, Picture-Word Learning Test immediate; PLTd, Picture-Word Learning Test delayed. Estimates represent the additional change in various cognitive performance tests per year in different subclinical thyroid status. Adjusted for sex, age, education, country, treatment, apo E genotype and test version where appropriate.