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. 2013 Mar 12;8(3):e58889. doi: 10.1371/journal.pone.0058889

Figure 2. Repeated subthreshold stimulation does not sensitize ionotropic receptors (IRs).

Figure 2

A, Recordings of neuronal activity from ac3 sensilla (large action potentials, Ir75abc neuron; small action potentials, Or35a neuron) upon before and after 20 s repeated butyric acid (Ba) stimulation (−7 v/v; 0.5 s, shaded area). Both stimulations fail to elicit a response. B, Dependence of normalized Ir75abc neuron spike frequency (fnorm) during 1st and 2nd subthreshold Etb stimulation (−7 v/v; 0.5 s) on the interval between stimulations (n = 12). C, Time course of fnorm for 1st and 2nd stimulation (interval 20 s, n = 12). D–F, Mean fnorm for Ir75abc (D), Ir41a (E) and Ir84a (F) neuron to repetitive subthreshold Ba (D), Dab (E) and Paa (F) stimulations (interval 20 s, n = 12). N.s.; Paired Wilcoxon Signed Ranks test.