Figure 4. Comparison of single step growth curves of parental and adapted CDV-A75/17^red using canine and human CD150-expressing target cells.

Vero-cSLAM cells (open circles) and Vero-hSLAM cells (closed circles) were infected with parental CDV-A75/17^red, and Vero-cSLAM cells (blue triangles) and Vero-hSLAM cells (red squares) were infected with human CD150-adapted CDV-A75/17^red (CDV-A75-ad) at a MOI of 0.01 and incubated for indicated times before harvesting cell bound plus released virus. The viruses were then titrated using the optimal target cells for each virus (n = 3, using 3 independently adapted viruses).