Table 6. Differentially enriched Gene Ontology biological processes among all target genes segmented by low and high hazard of ovarian cancer death or recurrence identified by set enrichment analyses.
| − hazard genes1 | + hazard genes2 | Loge 3 | FDR- | ||||
| Trait and GO Category | GO identifier | In GO | Not in GO | In GO | Not in GO | (odds ratio) | adjusted P-value4 |
| Survival | |||||||
| regulation of cellular metabolic process | GO:0031323 | 218 | 502 | 198 | 766 | 0.52 | 1.46E−02 |
| regulation of metabolic process | GO:0019222 | 229 | 491 | 214 | 750 | 0.49 | 1.47E−02 |
| Recurrence | |||||||
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | GO:0006139 | 117 | 175 | 321 | 1034 | 0.77 | 3.91E−05 |
| RNA processing | GO:0006396 | 29 | 263 | 49 | 1306 | 1.08 | 5.96E−03 |
| nitrogen compound metabolic process | GO:0006807 | 122 | 170 | 354 | 1001 | 0.71 | 1.94E−04 |
| regulation of gene expression | GO:0010468 | 84 | 208 | 237 | 1118 | 0.64 | 5.48E−03 |
| gene expression | GO:0010467 | 109 | 183 | 291 | 1064 | 0.78 | 3.91E−05 |
| regulation of transcription | GO:0045449 | 78 | 214 | 213 | 1142 | 0.67 | 5.48E−03 |
| cellular metabolic process | GO:0044237 | 264 | 223 | 492 | 668 | 0.47 | 8.33E−03 |
| cellular biosynthetic process | GO:0044249 | 106 | 186 | 342 | 1013 | 0.52 | 3.13E−02 |
| RNA metabolic process | GO:0016070 | 80 | 212 | 219 | 1136 | 0.67 | 5.48E−03 |
| transcription | GO:0006350 | 82 | 210 | 219 | 1136 | 0.71 | 3.22E−03 |
| regulation of nitrogen compound metabolic process | GO:0051171 | 84 | 208 | 237 | 1118 | 0.64 | 5.48E−03 |
| macromolecule biosynthetic process | GO:0009059 | 97 | 195 | 283 | 1072 | 0.63 | 5.42E−03 |
− hazard genes: number of genes that have a negative association between the hazard of ovarian cancer death (higher survival) or recurrence and expression.
+ hazard genes: number of genes that have a positive association between the hazard of ovarian cancer death (lower survival) or recurrence and expression.
Loge(Odds Ratio): values >1 indicate that the category was more enriched among the genes that have a negative association with hazard than among the genes that have a positive association with hazard; values <1 indicate that the category was more enriched among the genes that have a positive association with hazard than among the genes that have a negative association with hazard; Extreme values indicate higher difference in the enrichment percentages between the negative and positive association groups. Values close to zero indicate similar enrichment percentages between positive and negative association groups.
FDR-adjusted P-value: False discovery rate adjusted P-value of the log odds ratio test. Enrichment at FDR-adjusted Pvalue <0.05) and ≥75 genes in the category.