Table 3. Predicted miRNAs targeting the 3′UTR of selected mRNAs important for granulopoiesis.
3′UTR | Cluster | miRNA |
Transcription factors | ||
RUNX1 | 1 | hsa-mir-106a, hsa-mir-146b, hsa-mir-17, hsa-mir-181d, hsa-mir-18a, hsa-mir-18b, hsa-mir-20b, hsa-mir-422a, hsa-mir-584, hsa-mir-874 |
2 | hsa-miR-363, hsa-mir-20b* | |
3 | – | |
4 | hsa-miR-7 | |
5 | hsa-mir-182, hsa-mir-185, hsa-mir-192, hsa-mir-194-1, hsa-mir-200c, hsa-mir-22, hsa-mir-22*,hsa-mir-28, hsa-mir-30e, hsa-mir-338-3p, hsa-mir-338-5p, hsa-mir-504, hsa-mir-628, hsa-mir-769 | |
6 | hsa-mir-148b, hsa-mir-15a, hsa-mir-15b, hsa-mir-23a, hsa-mir-23b, hsa-mir-27a, hsa-mir-30a, hsa-mir-30c-1, hsa-mir-424, hsa-mir-550-1,hsa-mir-625, hsa-mir-675. | |
CEBPε | 1 | hsa-mir-130a, hsa-mir-130b |
2 | – | |
3 | – | |
4 | – | |
5 | – | |
6 | hsa-mir-454 | |
PU1/SPI1 | 1 | hsa-mir-155 |
2 | hsa-mir-150 | |
3 | – | |
4 | – | |
5 | – | |
6 | hsa-mir-491-5p | |
Cell cycle regulators | ||
CDK2 | 1 | – |
2 | – | |
3 | – | |
4 | – | |
5 | hsa-mir-200c, hsa-mir-29a, hsa-mir-29b | |
6 | hsa-mir-140-5p | |
CDK4 | 1 | hsa-mir-486-5p |
2 | – | |
3 | – | |
4 | – | |
5 | – | |
6 | – | |
CDK6 | 1 | – |
2 | – | |
3 | – | |
4 | – | |
5 | hsa-mir-22, hsa-mir-26a | |
6 | hsa-mir-15a, hsa-mir-26b | |
P27/CDKN1B | 1 | hsa-mir-222, hsa-mir-222*, hsa-mir-155, hsa-mir-181b, hsa-mir-181d |
2 | hsa-mir-196b, hsa-mir-152 | |
3 | – | |
4 | – | |
5 | hsa-mir-194, hsa-mir-200c, hsa-mir-595 | |
6 | hsa-mir-24, hsa-mir-148 |
The table lists differentially expressed miRNAs from the array data with predicted targets in the 3′UTRs of mRNAs important in granulopoiesis.