Table 1. Wnt signaling in neuroimmune interactions.

Protein	Source	Role in the immune/neural systems	Signaling	Refs
Wnt1	Activated astrocytes (VM and striatal); activated endothelial cells; hippocampal neurons (HNs)	Promotes survival and neuroprotection of midbrain DA neurons; rescues SVZ stem/progenitor cells; induces extravasation of activated T cells; promotes astrocyte–neuron and astrocyte–microglia crosstalk; protects HNs against inflammatory/oxidative insult, in vivo/in vitro	Canonical/β-catenin	[8,10,17,63,79,80]
Wnt2	Mouse macrophages	ND	Canonical/β-catenin	[59]
Wnt2b	Activated endothelial cells	Promotes extravasation of activated T cells	ND	[63]
Wnt3a	Activated macrophages; neural stem/precursor cells; hippocampus, HNs	Anti-inflammatory in macrophages; promotes self-renewal, clonal expansion, and neurogenesis of SVZ and SGZ stem/progenitor cells; protects hippocampus, HNs, and adult hippocampal stem/precursors (in vivo/in vitro)	Canonical/β-catenin	[4,5,40,42,46,47, 51,53,71,73,86]
Wnt4	Activated endothelial cells	Promotes extravasation of activated T cells	Canonical/β-catenin	[63]
Wnt5a	Activated CD4+ T cells and human macrophages; activated endothelial cells, astrocytes, and microglia	Stimulates chemokine-directed T cell migration; inhibits DC differentiation; tolerogenic on DCs; proinflammatory in macrophages and microglia; promotes autocrine endothelial inflammation; promotes proinflammatory response in microglia	Non-canonical/β-catenin [9,18,40,58,60, 62-64]
Wnt7a	ND	Promotes self-renewal, clonal expansion, and neurogenesis of SGZ stem/progenitor cells	TLX/catenin and Wnt–Ca2+	[46,48]
Wnt7b	Mouse macrophages	Promotes programmed cell death of vascular endothelial cells and tissue healing	Wnt–Ca2+	[59,61]
Wnt8b	Activated endothelial cells	Promotes extravasation of activated T cells	Canonical/β-catenin	[63]
Wnt10b	Mouse macrophages	ND	Canonical/β-catenin	[59]