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. Author manuscript; available in PMC: 2013 Mar 12.
Published in final edited form as: Trends Mol Med. 2013 Jan 22;19(3):197–209. doi: 10.1016/j.molmed.2012.12.007

Figure 2. Schematic representation of the human CYP19 gene reveals the alternative splicing and tissue specific promoters.

Figure 2

The regulatory region (~93 kb) contains 10 tissue-specific promoters and initial exons that differ in both location and size. These are alternatively spliced onto a common site just upstream of the ATG codon in exon II. The untranslated Exon I of mRNA species may be viewed as a signature of the tissue-specific promoter. Different promoters are named according to the 5'-UTR of their corresponding mature mRNA species. The coding region (~30 kb) spans exon II–X and is identical in all tissues and encodes the aromatase protein.