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. Author manuscript; available in PMC: 2013 Mar 12.
Published in final edited form as: Trends Mol Med. 2013 Jan 22;19(3):197–209. doi: 10.1016/j.molmed.2012.12.007

Figure 3. Schematic diagram of the two human ERs, ERα and ERβ.

Figure 3

Both receptors consist of six functional domains, including the domain A/B at the N-terminal for protein–protein interactions and transcriptional activation of target-gene expression, the domain C for DNA-binding domain (DBD), domain D for the nuclear translocation signal, and domain E/F at the C-terminal for ligand-binding domain (LBD) and the ligand-dependent activation function AF-2. The percentage homology between the two receptors is indicated.