Table 1.

Tissue-specific distribution of ERs^a

ER subtypes	Distribution in peripheral tissues (a)
ER α	primarily expressed in the uterus, epididymis, bone, breast, liver, kidney, white adipose tissue, stroma of prostate, theca and interstitial cells of ovary, and leydig cells of testes
ER β	primarily expressed in the colon, testis, bone marrow, vascular endothelium, lung, bladder, epithelium of prostate, granulosa cells of ovary
GPR30	detected in adrenal medulla, renal pelvis and ovary
ER-X	enriched in the uterus and lung of the postnatal rodent; almost undetectable in the normal adult

ER subtypes	Distribution in the brain (b)
	intense	moderate	weak	Absent
ER α	Amygdala; Bed nucleus of the stria terminals; Periqueductal gray; Preoptic area.	Allocortex; Hypothalamus; Locus coeruleus; Spinal trigeminal nucleus	Hippocampus; Raphe nuclei; Zona incerta.	Anterior tegmental nucleus; Cerebellum; Globus pallidus; Inferior olive nucleus; Isocortex; Ponti nenuclei; Thalamus; Substantial nigra; Superior olive nucleus; Ventral tegmental area.
ER β	Amygdala; Bed nucleus of the stria terminals; Raphe nuclei; Substantial nigra.	Allocortex; Globus pallidus; Hippocampus; Locus coeruleus; Preoptic area; Ventral tegmental area;	Anterior tegmental nucleus; Hypothalamus; Inferior olive nucleus; Isocortex; Periqueductal gray; Pontine nuclei; Spinal trigeminal nucleus; Superior olive nucleus; Thalamus.	Cerebellum; Zona incerta.
GPR30	Allocortex; Anterior tegmental nucleus; Cerebellum; Hippocampus; ypothalamus; Isocortex; Locus coeruleus; Pontine nuclei; Preoptic area; Spinal trigeminal nucleus; Superior olive nucleus.	Periqueductal gray.	Amygdala; Bed nucleus of the stria terminals; Raphe nuclei; Substantial nigra (reticular);	Ventral tegmental area
ER-X	enriched in the fetal baboon brain and the neocortex of the postnatal rodent, ; almost undetectable in the normal adult

^aAdapted from [24–29]