Table 1.
Members of the intracellular signaling pathways
| Gene name | Domain(s) | Contig(s) | nCF | nCH | nIF | nIH | nIF:nCF | nIH:nCH |
|---|---|---|---|---|---|---|---|---|
| Toll pathway | ||||||||
| Spätzle | 2287 | 11.8 | 68.8 | 42.3 | 274.1 | 3.6 | 4.0 | |
| Toll | 5599, 6893, 14282 | 106.64 | 164.6 | 235.6 | 247.9 | 2.2 | 1.5 | |
| MyD88 | Death, TIR | 864 | 118.5 | 137.5 | 181.2 | 201.2 | 1.5 | 1.5 |
| Tube | Death, PK | 1313 | 23.7 | 127.7 | 199.4 | 102.1 | 8.4 | 0.8 |
| Pelle | Death, PK | 2038 | 0.0 | 17.2 | 60.4 | 37.9 | 5.1 | 2.2 |
| Pellino | 292 | 71.1 | 147.4 | 175.2 | 189.6 | 2.5 | 1.3 | |
| Cactus | ANK-2 | 1044, 3381, 15574 | 118.5 | 260.3 | 1190.2 | 452.0 | 10.0 | 1.7 |
| Lesswright | UBC | 4591 | 11.8 | 167.0 | 54.4 | 198.3 | 4.6 | 1.2 |
| aPKC | PK, PK C-domain | 5708, 7433 | 0.0 | 39.3 | 0.0 | 37.9 | 0/0 | 1.0 |
| Ref(2)P | PBI, ZZ Zinc finger | 5971 | 23.7 | 78.6 | 24.2 | 64.2 | 1.0 | 0.8 |
| Rel/Dorsal | Rel domain | 2384 | 82.9 | 198.9 | 108.7 | 242.0 | 1.3 | 1.2 |
| ECSIT | ECSIT | 4177 | 0.0 | 14.7 | 6.0 | 20.4 | 0.5 | 1.4 |
| Tollip-d | CUE | 4949 | 71.1 | 0.0 | 72.5 | 0.0 | 1.0 | 0/0 |
| Tollip-v | C2, CUE | 731 | 59.2 | 311.9 | 48.3 | 344.1 | 0.8 | 1.1 |
| Smt3 | Sumo | 7946 | 59.2 | 167.0 | 96.7 | 262.5 | 1.6 | 1.6 |
| Aos1 | Aos1-SUMO | 5438 | 35.5 | 56.5 | 24.2 | 93.3 | 0.7 | 1.7 |
| Uba2 | Uba2-SUMO | 890 | 11.8 | 140.0 | 30.2 | 210.0 | 2.6 | 1.5 |
| Misshapen | PK, CNH | 289 | 106.6 | 311.9 | 181.2 | 259.5 | 1.7 | 0.8 |
|
| ||||||||
| IMD pathway | ||||||||
| IMD | Death | 2368 | 35.5 | 61.4 | 78.5 | 67.1 | 2.2 | 1.1 |
| FADD | Death, DID | 342 | 876.8 | 122.8 | 531.6 | 157.5 | 0.6 | 1.3 |
| Dredd | Caspase (Peptidase-C14) | 1615, 14535, 15028 | 71.1 | 149.8 | 139.0 | 201.2 | 2.0 | 1.3 |
| IAP2 | BIR/Inhibitor of apoptosis | 1174, 7327, 8290, 9234 | 106.6 | 98.2 | 30.2 | 110.8 | 0.3 | 1.1 |
| Ubc13/ben | UBC | 2901 | 82.9 | 117.9 | 96.7 | 247.9 | 1.2 | 2.1 |
| Uev1A | UBC | 3326 | 154.0 | 368.4 | 217.5 | 411.2 | 1.4 | 1.1 |
| TAK1 | PTK | 8422 | 0.0 | 4.9 | 6.0 | 17.5 | 0.5 | 3.6 |
| Tab2 | CUE | 1637 | 0.0 | 44.2 | 30.2 | 43.7 | 2.6 | 1.0 |
| IKKβ | PK | 5609 | 11.8 | 14.7 | 6.0 | 2.9 | 0.5 | 0.2 |
| IKKγ | 1049 | 11.8 | 93.3 | 30.2 | 107.9 | 2.6 | 1.2 | |
| Relish-2A | PEST | 15531, 15532 | 11.8 | 61.4 | 96.7 | 72.9 | 8.2 | 1.2 |
| Relish-2B | Rel homology domain | 4802 | 23.7 | 103.2 | 151.0 | 192.5 | 6.4 | 1.9 |
| Ntf2 | NTF2 | 6033, 8947 | 118.5 | 169.5 | 157.1 | 332.4 | 1.3 | 2.0 |
| Serpent | ZnF-GATA | 4249, 17496 | 485.8 | 582.1 | 163.1 | 501.6 | 0.3 | 0.9 |
| Sickie | 5128, 7157 | 35.5 | 2.5 | 18.1 | 64.2 | 0.5 | 26.1 | |
| Caspar | UBX | 2428 | 11.8 | 27.0 | 36.2 | 52.5 | 3.1 | 1.9 |
| POSH | SH3 | 1777, 5429 | 47.4 | 338.9 | 66.5 | 309.1 | 1.4 | 0.9 |
|
| ||||||||
| MAPK pathway with JNK and p38 branches | ||||||||
| Eiger | TNF | 1020 | 497.6 | 9.8 | 380.6 | 78.7 | 0.8 | 8.0 |
| Cdc42 | Cdc42 | 647 | 130.3 | 579.6 | 114.8 | 621.1 | 0.9 | 1.1 |
| Dsor1 | PK | 6185 | 11.8 | 34.4 | 0.0 | 29.2 | 0.0 | 0.9 |
| Rac1 | Rac1 | 3605 | 0.0 | 27.0 | 30.2 | 35.0 | 2.6 | 1.3 |
| Ras85D | Ras | 73, 132, 205, 1185 | 651.7 | 1350.8 | 555.8 | 1991.7 | 0.9 | 1.5 |
| MLK1 | PK, PTK, SH3 | 1825, 1841 | 59.2 | 117.9 | 84.6 | 198.3 | 1.4 | 1.7 |
| MEKK1 | PK | 1947 | 11.8 | 49.1 | 0.0 | 20.4 | 0.0 | 0.4 |
| Licrone/MKK3 | PK-MKK3-6 | 2351 | 82.9 | 108.1 | 114.8 | 122.5 | 1.4 | 1.1 |
| p38 | PK | 7214 | 23.7 | 63.9 | 42.3 | 93.3 | 1.8 | 1.5 |
| MKK4 | PK-MKK4 | 3655 | 35.5 | 63.9 | 30.2 | 29.2 | 0.9 | 0.5 |
| Hem | PK-MKK7 | 4608 | 0.0 | 24.6 | 6.0 | 23.3 | 0.5 | 1.0 |
| JNK | PK | 3082 | 23.7 | 7.4 | 24.2 | 40.8 | 1.0 | 5.5 |
| FOS | bZIP | 4904 | 23.7 | 95.8 | 48.3 | 177.9 | 2.0 | 1.9 |
| Jra | bZIP | 13290, 13291 | 71.1 | 186.7 | 108.7 | 186.6 | 1.5 | 1.0 |
| Aop | SAM-PNT, ETS | 1136 | 0.0 | 125.3 | 36.2 | 154.6 | 3.1 | 1.2 |
| MASK | ANK, KH-I | 225, 4036 | 106.6 | 206.3 | 157.1 | 265.4 | 1.5 | 1.3 |
| JAK-STAT pathway | ||||||||
| Domeless | SH2 | 7557, 9588 | 11.8 | 27.0 | 30.2 | 17.5 | 2.6 | 0.7 |
| JAK/Hopscotch | PTK, SH2, B41 | 20 | 272.5 | 498.6 | 241.7 | 250.8 | 0.9 | 0.5 |
| STAT | SH2, Protein | 2221, 14109 | 106.6 | 135.1 | 24.2 | 102.1 | 0.2 | 0.8 |
| PIAS | Interacting, MIZ/SP RING | 602 | 23.7 | 113.0 | 42.3 | 119.6 | 1.8 | 1.1 |
| SOCS | SH2, SOCS box | 1187, 6886 | 11.8 | 159.6 | 30.2 | 125.4 | 2.6 | 0.8 |
| Stam | VHS | 13543 | 0.0 | 19.6 | 6.0 | 20.4 | 0.5 | 1.0 |
*
Genes reported by Zhang et al. (2011) are underlined. nCF, nCH, nIF and nIH are normalized read numbers and, for genes with two or more contigs, they represent the total values. When nCF = 0, adjusted NRN for nIF (italics) is calculated as nIF × 825/9775; when nCH = 0, adjusted NRN for nIH (italics) is calculated as nIH × 3980/9775.