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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Cancer Discov. 2012 Nov 21;3(3):338–349. doi: 10.1158/2159-8290.CD-12-0313

Figure 5. NF1 protein expression in human melanomas.

Figure 5

A) NF1 protein levels in a panel of 11 human melanomas cell lines as determined by immunoblotting. Four lines (with asterisks) exhibit low or no NF1 expression. Three lines (underlined) harbor NF1 mutations. B) NF1 reconstitution in A375 cells potently suppresses the growth of xenografts in mice. Tumor size is shown on left, protein expression in right panel. C) Tissue microarray analysis of NF1 in human malignant and metastatic melanomas. Positive NF1 staining in nevus is shown in left panel. A magnification of the inset box is shown in the middle panel. Negative NF1 staining in human melanoma is shown in the right panel.