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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Epilepsy Behav. 2012 Dec 12;26(3):247–252. doi: 10.1016/j.yebeh.2012.10.027

Figure 4. Reduction in OCT scattering signal prior to seizure onset.

Figure 4

Stable baseline OCT images were obtained for 5 minutes prior to administration of PTZ (red line). Inset shows region of interest (ROI) in brain cortex OCT image in which near-infrared (NIR) backscatter intensity was analyzed at every time point (every 5 seconds or 0.2 Hz) indicated by the blue circles. Approximately 10% reduction in intensity was observed prior to generalized seizure onset at 10 minutes (black line). These data provide proof-of-principle for real-time OCT-based seizure detection with excellent optical stability, sensitivity and temporal resolution. Courtesy of Eberle et al. (unpublished data).