Table 2.
Distribution of GAG repeat genotypes and lung and aerodigestive tract cancer risk
| GAG Genotype | Controls n (%) | Lung Cancer Cases* | Aerodigestive Tract Cancer Cases† | ||
|---|---|---|---|---|---|
|
| |||||
| n (%) | OR (95% CI) | n (%) | OR (95% CI) | ||
| GAG-9/9 | 52 (9.6) | 20 (5.7) | 1.00 (reference) | 9 (4.5) | 1.00 (reference) |
| GAG-7/7 | 190 (35.3) | 133 (38.3) | 1.87 (1.00–3.51) | 79 (39.5) | 2.56 (1.16–5.63) |
| GAG-7/8 | 79 (14.7) | 45 (12.9) | 1.68 (0.83–3.42) | 35 (17. 5) | 2.60 (1.10–6.12) |
| GAG-7/9 | 155 (28.8) | 102 (29.3) | 1.67 (0.88–3.16) | 55 (27.5) | 1.94 (0.87–4.35) |
| GAG-8/8 | 15 (2.7) | 6 (1.7) | 1.16 (0.36–3.73) | 5 (2.5) | 1.83 (0.50–6.68) |
| GAG-8/9 | 32 (5.9) | 23 (6.6) | 2.23 (0.96–5.16) | 16 (8.0) | 3.09 (1.16–8.22) |
| GAG-4/4 | 0 | 2 (0.5) | ‡ | 0 | ‡ |
| GAG-7/10 | 9 (1.6) | 12 (3.4) | ‡ | 0 | ‡ |
| GAG-8/10 | 1 (0.1) | 1 (0.3) | ‡ | 0 | ‡ |
| GAG-9/10 | 2 (0.3) | 3 (0.8) | ‡ | 0 | ‡ |
| GAG-4/9 | 0 | 0 | ‡ | 1(0.5) | ‡ |
| GAG-4/7 | 0 | 0 | ‡ | 0 | ‡ |
| GAG-10/10 | 2(0.3) | 0 | ‡ | 0 | ‡ |
*
OR adjusted for age, sex, body mass index and smoking history (categorical).
†
OR adjusted for age, sex, body mass index, smoking history (categorical) and the amount of alcohol intake.
‡
Minor genotypes not included in statistical model.