Table 1.

PfRH5 polymorphisms and invasion of native and transformed P. falciparum 7G8 and LC12 lines

		PfRH5 polymorphisms							Erythrocyte invasion rate (% ± S.E.)a
Parasite lineb	Transfection plasmid	204	347	358	362	407	410	429	A. nancymaae	Rat	Mouse
7G8	—	I	N	Y	E	I	I	K	0.4 ± 0.2c	0.2 ± 0.2	N.D.d
LC12	—	K	N	Y	E	V	I	K	55.4 ± 4.2c	25.7 ± 2.9	N.D.
7G8204I/407I	pHD22Y-rh57G8	I	N	Y	E	I	I	K	2.1 ± 0.4	0.2 ± 0.2	58.4 ± 29.4
7G8204K/407V	pHD22Y-rh5LC12	K	N	Y	E	V	I	K	38.7 ± 7.6	23.5 ± 2.3	57.8 ± 9.9
7G8204I/407V	pHD22Y-rh5LC12	I	N	Y	E	V	I	K	4.9 ± 3.0	0.0 ± 0.0	N.D.
LC12204K/407V	pHD22Y-rh5LC12	K	N	Y	E	V	I	K	43.2 ± 7.3	20.5 ± 3.6	52.0 ± 2.9
LC12204I/407I	pHD22Y-rh57G8	I	N	Y	E	I	I	K	4.6 ± 1.0	0.1 ± 2.9	48.5 ± 4.5
LC12204K/407I	pHD22Y-rh57G8	K	N	Y	E	I	I	K	34.6 ± 5.4	20.4 ± 2.7	N.D.
7G8204R	pHD22Y-rh5PaloAlto	R	N	Y	E	I	I	K	29.4 ± 6.6	26.7 ± 4.0	N.D.
7G8347D	pHD22Y-rh5SantaLucia	I	D	Y	E	I	I	K	16.8 ± 2.6	0.0 ± 0.0	N.D.
7G8347Y/429N	pHD22Y-rh5MalCamp	I	Y	Y	E	I	I	N	26.8 ± 2.0	0.5 ± 0.5	53.8 ± 10.3
7G8358F/362D	pHD22Y-rh5FVO	I	N	F	D	I	I	K	71.6 ± 5.7	0.0 ± 0.0	22.8 ± 0.5
7G8410M	pHD22Y-rh5Dd2	I	N	Y	E	I	M	K	2.0 ± 0.2	0.0 ± 0.0	N.D.
7G8429N	pHD22Y-rh5N429	I	N	Y	E	I	I	N	2.2 ± 1.4	0.0 ± 0.0	41.9 ± 5.3

^aRelative to rates of invasion into human erythrocytes.

^bParasite transfectants 7G8^204I/407I, 7G8^204K/407V, 7G8^204I/407V, LC12204K/407V, LC12^204I/407I and LC12^204K/407I previously reported as 7G8^II, 7G8^KV, 7G8^IV, LC12^KV, LC12^II and LC12^KI, respectively [23].

^cAs reported in [23].

^dN.D., not determined.