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. Author manuscript; available in PMC: 2014 Apr 3.
Published in final edited form as: Neuroscience. 2013 Jan 26;235:215–225. doi: 10.1016/j.neuroscience.2013.01.029

FIGURE 2. GluK4 knockout mice display hyperlocomotion and impaired PPI.

FIGURE 2

(A) GluK4 knockout mice (n = 12) traveled significantly greater distances throughout the one-hour open field trial than wild-type mice (n = 15; two-way ANOVA for distance traveled, effect of genotype, p = 0.0076), indicating basal hyperactivity.

(B) The acoustic startle response was significantly decreased in GluK4 knockout mice (n = 12) relative to wild-type mice (n = 15) at stimulus intensities of 110 and 120 dB.

(C) GluK4 knockout mice (n = 12) displayed reduced PPI relative to wild-type mice (n = 15) at pre-pulse tones of 6 and 12 dB above background, indicating that knockouts had deficits in sensorimotor gating. Data represent mean ± SEM. **p < 0.01, ***p < 0.001.