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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Chem Rev. 2012 Nov 12;113(4):2584–2667. doi: 10.1021/cr3002142

Figure 50.

Figure 50

Top: Schematic of the DNA prism. The SEM images in the insets highlight different regions of the device. Bottom: Illustration of the separation mechanism. At t0 both the long and short fragment travel in the strong field direction. At t1 the field is switched to the weak field in a new direction. The long DNA molecule cannot get all the way around the corner, but the smaller molecule can. At t2 the field is switched back to the strong field and the long DNA travel down the same channel while the shorter DNA is now in a new channel. Reprinted with permission from Ref.498 Copyright 2002 Nature Publishing Group.