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. Author manuscript; available in PMC: 2014 Apr 10.
Published in final edited form as: Chem Rev. 2012 Nov 12;113(4):2584–2667. doi: 10.1021/cr3002142

Figure 59.

Figure 59

Device design for loading DNA into channels in the Odijk regime. (a) SEM micrograph of 85 nm nanochannels made by nanoimprint lithography that are subsequently thinned to channels on the order of 10 nm. The scale bar is 500 nm. Also included is the diffraction gradient lithography schematic (right), showing the gradual slope change approaching the nanochannels. (b) Schematic of microchannel-nanochannel interface (top), and fluorescence micrograph of the loading process. Adapted with permission from Ref.589,590 Copyright 2002 American Institute of Physics.