Table 2.
Brain stem region C1 PNMT and c-fos expression in male rats exposed to AIE and challenged with alcohol on PND 70–71
Group | Treatmenta | Number of PNMT-ir cells per section in C1 | Number of colocalized c-fos-ir and PNMT-ir cells per section in C1 |
---|---|---|---|
Male | Control/vehicle ig | 68.6 ± 13.6 | 0.6 ± 0.2 |
Control/alcohol ig | 78.1 ± 11.8 | 4.3 ± 0.9b | |
AIE/vehicle ig | 79.2 ± 3.9 | 1.8 ± 0.4c | |
AIE/alcohol ig | 92.5 ± 6.4 | 6.0 ± 0.6b,c |
Male rats were exposed to alcohol vapor (AIE) or air (Control) from PND 28–42, then injected with alcohol (4.5 g/kg, ig) or vehicle at PND 70–71. Values are mean ± SEM, n=4–6 rats per group.
P<0.001, alcohol challenge vs. vehicle.
P<0.05, AIE vs. control.