Distribution and survival of patients with acute myeloid leukemia (AML) in the test set (Netherlands Set 2+, n = 480) according to or predicted by integrated risk categories. (A) Scheme of reclassification of the four European LeukemiaNet (ELN) risk groups into three new integrated risk groups by integrating the 24-gene signature classification (ie, low or high) with ELN risk classification. (B) Distribution of the whole set of patients, those age < 60 years, and those age > 60 years according to integrated risk class criteria. (C, D, E) Overall (left panels) and event-free survival (right panels) rates of (C) the whole set of patients, (D) those age < 60 years, and (E) those age > 60 years predicted by integrated risk categories.