Table 1.
Characteristics and Multivariate* Predictors of Receipt of Adjuvant Intravesical BCG Among Patients Diagnosed With NMIBC Registered in the SEER-Medicare Database, 1991-2002 (N = 23,932)
| Category | BCG (n = 5,885) |
No BCG (n = 18,047) |
Multivariate Predictors of Receipt of BCG |
|||
|---|---|---|---|---|---|---|
| No. | % | No. | % | OR | 95% CI | |
| Age, years† | ||||||
| Mean | 75.9 | 76.9 | ||||
| 65-69 | Referent | |||||
| 70-74 | 1.05 | 0.95 to 1.16 | ||||
| 75-79 | 0.95 | 0.86 to 1.05 | ||||
| 80-84 | 0.88 | 0.79 to 0.98 | ||||
| ≥ 85 | 0.51 | 0.45 to 0.58 | ||||
| Sex† | ||||||
| Male | 4,477 | 76 | 13,177 | 73 | Referent | |
| Female | 1,408 | 24 | 4,870 | 27 | 0.99 | 0.92 to 1.07 |
| Race/ethnicity† | ||||||
| White | 5,434 | 92 | 16,904 | 94 | Referent | |
| Black | 170 | 3 | 517 | 3 | 0.94 | 0.78 to 1.14 |
| Hispanic | 45 | 1 | 137 | 1 | 0.86 | 0.60 to 1.23 |
| Other | 223 | 4 | 438 | 22 | 1.42 | 1.20 to 1.68 |
| Grade† | ||||||
| Well differentiated | 505 | 9 | 4,111 | 23 | Referent | |
| Moderately differentiated | 2,018 | 34 | 8,606 | 48 | 1.85 | 1.66 to 2.05 |
| Poorly differentiated | 1,993 | 34 | 3,363 | 19 | 4.07 | 3.63 to 4.56 |
| Undifferentiated | 659 | 11 | 847 | 5 | 4.60 | 3.97 to 5.32 |
| Unknown | 710 | 12 | 1,120 | 6 | 3.88 | 3.37 to 4.47 |
| Stage† | ||||||
| Tis | 679 | 12 | 862 | 5 | Referent | |
| Ta | 2,706 | 46 | 12,178 | 67 | 2.67 | 2.37 to 3.02 |
| T1 | 2,257 | 38 | 3,750 | 21 | 1.91 | 1.77 to 2.05 |
| Other | 243 | 4 | 1,257 | 7 | 0.76 | 0.66 to 0.89 |
| No. of comorbidities | ||||||
| 0 | 3,342 | 57 | 10,262 | 57 | Referent | |
| 1 | 1,480 | 25 | 4,432 | 25 | 1.01 | 0.94 to 1.09 |
| ≥ 2 | 1,063 | 18 | 3,353 | 19 | 0.94 | 0.86 to 1.02 |
| Marital status† | ||||||
| Single/divorced | 1,708 | 29 | 6,048 | 34 | Referent | |
| Married | 3,941 | 67 | 11,242 | 62 | 0.86 | 0.80 to 0.92 |
| Unknown | 236 | 4 | 757 | 4 | 0.87 | 0.75 to 1.03 |
| Residence† | ||||||
| Urban | 5,390 | 92 | 16,331 | 90 | 1.16 | 1.03 to 1.30 |
| Rural | 495 | 8 | 1,716 | 10 | Referent | |
| SES quintile | ||||||
| 1st | 1,129 | 19 | 3,340 | 19 | 1.08 | 0.97 to 1.19 |
| 2nd | 1,103 | 19 | 3,521 | 20 | 0.99 | 0.90 to 1.10 |
| 3rd | 1,133 | 19 | 3,687 | 20 | 0.92 | 0.84 to 1.02 |
| 4th | 1,213 | 21 | 3,694 | 20 | 0.98 | 0.89 to 1.08 |
| 5th | 1,307 | 22 | 3,805 | 21 | Referent | |
Abbreviations: BCG, Bacillus Calmette-Guérin; NMIBC, non–muscle-invasive bladder cancer; OR, odds ratio; SEER, Surveillance, Epidemiology, and End Results; SES, socioeconomic.
*
Adjusted for all other variables in the table and year of diagnosis.
†
Statistically significant differences exist between BCG and no BCG groups for these variables (χ2 significance test).