Table 3.
HLA-B single amino acid polymorphisms**
| Positions† | Amino acid | Patients (176) n (%) | Controls (329) n (%) | Odds Ratio | Pu value* | Pc value* |
|---|---|---|---|---|---|---|
| 9 | D | 29(16.48) | 52(15.81) | 1.0 | 0.84 | NS |
| 9 | H | 57(32.39) | 118(35.87) | 0.9 | 0.43 | NS |
| 11 | A | 154(87.50) | 303(92.10) | 1.0 | 0.09 | NS |
| 11 | S | 85(48.30) | 174(52.89) | 0.9 | 0.33 | NS |
| 12 | M | 149(84.66) | 298(90.58) | 0.9 | 0.05 | NS |
| 12 | V | 95(53.98) | 187(56.84) | 0.9 | 0.54 | NS |
| 24 | A | 92(52.27) | 172(52.28) | 1.0 | 1.00 | NS |
| 24 | S | 110(62.50) | 205(62.31) | 1.0 | 0.97 | NS |
| 24 | T | 88(50.00) | 173(52.58) | 1.0 | 0.58 | NS |
| 32 | L | 79(44.89) | 162(49.24) | 0.9 | 0.35 | NS |
| 41 | T | 80(45.45) | 157(47.72) | 1.0 | 0.63 | NS |
| 45 | E | 115(65.34) | 210(63.83) | 1.0 | 0.74 | NS |
| 45 | K | 72(40.91) | 147(44.68) | 0.9 | 0.42 | NS |
| 45 | M | 43(24.43) | 83(25.23) | 1.0 | 0.84 | NS |
| 45 | T | 71(40.34) | 137(41.64) | 1.0 | 0.78 | NS |
| 46 | A | 43(24.43) | 83(25.23) | 1.0 | 0.84 | NS |
| 62 | G | 19(10.80) | 37(11.25) | 1.0 | 0.88 | NS |
| 63 | E | 122(69.32) | 245(74.47) | 0.9 | 0.22 | NS |
| 63 | N | 136(77.27) | 269(81.76) | 0.9 | 0.23 | NS |
| 65 | R | 22(12.50) | 40(12.16) | 1.0 | 0.91 | NS |
| 66 | N | 22(12.50) | 40(12.16) | 1.0 | 0.91 | NS |
| 67 | C | 49(27.84) | 78(23.71) | 1.2 | 0.31 | NS |
| 67 | F | 68(38.64) | 139(42.25) | 0.9 | 0.43 | NS |
| 67 | M | 22(12.50) | 40(12.16) | 1.0 | 0.91 | NS |
| 67 | S | 110(62.50) | 215(65.35) | 1.0 | 0.52 | NS |
| 67 | Y | 56(31.82) | 97(29.48) | 1.1 | 0.59 | NS |
| 69 | A | 75(42.61) | 144(43.77) | 1.0 | 0.80 | NS |
| 70 | Q | 55(31.25) | 96(29.18) | 1.1 | 0.63 | NS |
| 70 | S | 22(12.50) | 40(12.16) | 1.0 | 0.91 | NS |
| 71 | A | 78(44.32) | 146(44.38) | 1.0 | 0.99 | NS |
| 74 | D | 107(60.80) | 193(58.66) | 1.0 | 0.64 | NS |
| 74 | Y | 151(85.80) | 291(88.45) | 1.0 | 0.39 | NS |
| 77 | N | 94(53.41) | 183(55.62) | 1.0 | 0.63 | NS |
| 77 | S | 155(88.07) | 276(83.89) | 1.0 | 0.21 | NS |
| 80 | I | 50(28.41) | 106(32.22) | 0.9 | 0.38 | NS |
| 80 | N | 154(87.50) | 277(84.19) | 1.0 | 0.32 | NS |
| 80 | T | 66(37.50) | 118(35.87) | 1.0 | 0.72 | NS |
| 81 | A | 94(53.41) | 183(55.62) | 1.0 | 0.63 | NS |
| 81 | L | 158(89.77) | 290(88.15) | 1.0 | 0.58 | NS |
| 82 | L | 104(59.09) | 197(59.88) | 1.0 | 0.86 | NS |
| 82 | R | 154(87.50) | 277(84.19) | 1.0 | 0.32 | NS |
| 83 | G | 154(87.50) | 277(84.19) | 1.0 | 0.32 | NS |
| 83 | R | 104(59.09) | 197(59.88) | 1.0 | 0.86 | NS |
| 94 | I | 85(48.30) | 163(49.54) | 1.0 | 0.79 | NS |
| 95 | I | 91(51.70) | 166(50.46) | 1.0 | 0.79 | NS |
| 95 | L | 143(81.25) | 256(77.81) | 1.0 | 0.37 | NS |
| 95 | W | 49(27.84) | 106(32.22) | 0.9 | 0.31 | NS |
| 97 | R | 139(78.98) | 245(74.47) | 1.1 | 0.26 | NS |
| 97 | S | 80(45.45) | 145(44.07) | 1.0 | 0.77 | NS |
| 97 | T | 35(19.89) | 83(25.23) | 0.8 | 0.18 | NS |
| 97 | W | 24(13.64) | 23(6.99) | 2.0 | 0.01 | NS |
| 103 | L | 70(39.77) | 103(31.31) | 1.3 | 0.06 | NS |
| 113 | Y | 85(48.30) | 147(44.68) | 1.1 | 0.44 | NS |
| 114 | D | 133(75.57) | 241(73.25) | 1.0 | 0.57 | NS |
| 114 | N | 122(69.32) | 227(69.00) | 1.0 | 0.94 | NS |
| 116 | D | 52(29.55) | 103(31.31) | 0.9 | 0.68 | NS |
| 116 | F | 47(26.70) | 67(20.36) | 1.3 | 0.10 | NS |
| 116 | L | 28(15.91) | 48(14.59) | 1.1 | 0.69 | NS |
| 116 | S | 72(40.91) | 135(41.03) | 1.0 | 0.98 | NS |
| 116 | Y | 108(61.36) | 221(67.17) | 0.9 | 0.19 | NS |
| 131 | R | 89(50.57) | 173(52.58) | 1.0 | 0.67 | NS |
| 131 | S | 158(89.77) | 299(90.88) | 1.0 | 0.69 | NS |
| 143 | S | 14(7.95) | 37(11.25) | 0.7 | 0.24 | NS |
| 147 | L | 14(7.95) | 37(11.25) | 0.7 | 0.24 | NS |
| 152 | E | 108(61.36) | 188(57.14) | 1.1 | 0.36 | NS |
| 152 | V | 155(88.07) | 281(85.41) | 1.0 | 0.41 | NS |
| 156 | D | 63(35.80) | 111(33.74) | 1.1 | 0.64 | NS |
| 156 | L | 148(84.09) | 275(83.59) | 1.0 | 0.88 | NS |
| 156 | R | 40(22.73) | 80(24.32) | 0.9 | 0.69 | NS |
| 156 | W | 24(13.64) | 37(11.25) | 1.2 | 0.43 | NS |
| 158 | T | 17(9.66) | 33(10.03) | 1.0 | 0.89 | NS |
| 163 | E | 71(40.34) | 149(45.29) | 0.9 | 0.29 | NS |
| 163 | L | 123(69.89) | 248(75.38) | 0.9 | 0.18 | NS |
| 163 | T | 87(49.43) | 148(44.98) | 1.1 | 0.34 | NS |
| 167 | S | 46(26.14) | 87(26.44) | 1.0 | 0.94 | NS |
| 171 | H | 46(26.14) | 93(28.27) | 0.9 | 0.61 | NS |
| 177 | D | 81(46.02) | 162(49.24) | 0.9 | 0.49 | NS |
| 178 | K | 50(28.41) | 109(33.13) | 0.9 | 0.28 | NS |
| 180 | E | 81(46.02) | 162(49.24) | 0.9 | 0.49 | NS |
*Pu, uncorrected P values; Pc, corrected P values.
† Polymorphic amino acid positions 3, 9, 12, 14, 17, 19, 31, 35, 43, 44, 56, 62, 63, 65, 66, 67, 70, 73, 74, 76, 77, 79, 80, 81, 82, 83, 90, 95, 97, 99, 102, 105, 107, 109, 114, 116, 127, 142, 144, 149, 150, 151, 152, 156, 158, 161, 163, 166, 167, 171.
** Not displaying amino acid residues that were present in 90% or greater in both patient and
control groups, or were present in 10% or fewer in both patient and control groups.