Table 7.
HLA-DQ single amino acid polymorphisms**
| Positions† | Amino acid | Patients (178) n (%) | Controls (342) n (%) | Odds ratio | Pu value* | Pc value* |
|---|---|---|---|---|---|---|
| 9 | F | 56(31.46) | 97(28.36) | 1.1 | 0.46 | NS |
| 13 | A | 65(36.52) | 133(38.89) | 0.9 | 0.60 | NS |
| 14 | L | 57(32.02) | 123(35.96) | 0.9 | 0.37 | NS |
| 26 | G | 69(38.76) | 149(43.57) | 0.9 | 0.29 | NS |
| 26 | L | 149(83.71) | 266(77.78) | 1.1 | 0.11 | NS |
| 26 | Y | 65(36.52) | 133(38.89) | 0.9 | 0.60 | NS |
| 28 | S | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 30 | H | 84(47.19) | 146(42.69) | 1.1 | 0.33 | NS |
| 30 | S | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 30 | Y | 132(74.16) | 265(77.49) | 1.0 | 0.40 | NS |
| 37 | I | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 38 | A | 147(82.58) | 284(83.04) | 1.0 | 0.90 | NS |
| 38 | V | 110(61.80) | 237(69.30) | 0.9 | 0.09 | NS |
| 45 | E | 60(33.71) | 120(35.09) | 1.0 | 0.75 | NS |
| 46 | E | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 47 | F | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 52 | L | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 53 | L | 148(83.15) | 277(80.99) | 1.0 | 0.55 | NS |
| 53 | Q | 122(68.54) | 213(62.28) | 1.1 | 0.16 | NS |
| 55 | L | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 55 | P | 94(52.81) | 192(56.14) | 0.9 | 0.47 | NS |
| 55 | R | 130(73.03) | 231(67.54) | 1.1 | 0.20 | NS |
| 57 | A | 95(53.37) | 179(52.34) | 1.0 | 0.82 | NS |
| 57 | D | 132(74.16) | 261(76.32) | 1.0 | 0.59 | NS |
| 57 | V | 54(30.34) | 100(29.24) | 1.0 | 0.79 | NS |
| 66 | D | 83(46.63) | 167(48.83) | 1.0 | 0.63 | NS |
| 67 | I | 83(46.63) | 167(48.83) | 1.0 | 0.63 | NS |
| 70 | G | 110(61.80) | 194(56.73) | 1.1 | 0.27 | NS |
| 70 | R | 150(84.27) | 280(81.87) | 1.0 | 0.49 | NS |
| 71 | A | 57(32.02) | 122(35.67) | 0.9 | 0.41 | NS |
| 71 | K | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 71 | T | 144(80.90) | 277(80.99) | 1.0 | 0.98 | NS |
| 74 | A | 66(37.08) | 129(37.72) | 1.0 | 0.89 | NS |
| 74 | E | 144(80.90) | 277(80.99) | 1.0 | 0.98 | NS |
| 74 | S | 69(38.76) | 149(43.57) | 0.9 | 0.29 | NS |
| 75 | L | 144(80.90) | 277(80.99) | 1.0 | 0.98 | NS |
| 75 | V | 116(65.17) | 244(71.35) | 0.9 | 0.15 | NS |
| 77 | R | 105(58.99) | 225(65.79) | 0.9 | 0.13 | NS |
| 77 | T | 148(83.15) | 290(84.80) | 1.0 | 0.62 | NS |
| 84 | E | 122(68.54) | 213(62.28) | 1.1 | 0.16 | NS |
| 84 | Q | 148(83.15) | 277(80.99) | 1.0 | 0.55 | NS |
| 85 | L | 148(83.15) | 277(80.99) | 1.0 | 0.55 | NS |
| 85 | V | 122(68.54) | 213(62.28) | 1.1 | 0.16 | NS |
| 86 | A | 114(64.04) | 206(60.23) | 1.1 | 0.40 | NS |
| 86 | E | 148(83.15) | 277(80.99) | 1.0 | 0.55 | NS |
| 87 | F | 69(38.76) | 113(33.04) | 1.2 | 0.19 | NS |
| 87 | L | 148(83.15) | 277(80.99) | 1.0 | 0.55 | NS |
| 87 | Y | 69(38.76) | 134(39.18) | 1.0 | 0.93 | NS |
| 89 | G | 122(68.54) | 213(62.28) | 1.1 | 0.16 | NS |
| 89 | T | 148(83.15) | 277(80.99) | 1.0 | 0.55 | NS |
| 90 | I | 122(68.54) | 213(62.28) | 1.1 | 0.16 | NS |
| 90 | T | 148(83.15) | 277(80.99) | 1.0 | 0.55 | NS |
*Pu, uncorrected P values; Pc, corrected P values.
† Polymorphic amino acid positions 9, 13, 14, 23, 26, 27, 28, 30, 37, 38, 45, 46,47, 52, 53, 55, 56, 57, 60 66, 67, 70, 71, 74, 75, 77, 84, 85, 86, 87, 89, 90.
** Not displaying amino acid residues that were present in 90% or greater in both patient and control groups, or were present in 10% or fewer in both patient and control groups.