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. 2013 Mar 13;7:23. doi: 10.3389/fncel.2013.00023

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Copyright © 2013 Song, Volynski, Brenner, Ushkaryov, Walker and Semyanov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Tonic GABA_A current produced by an increase in vesicular GABA release is regulated by mGAT1, but not mGAT3/4. (A) Top: Representative traces showing an increase in I_hold 10 min after LTX^N4C (gray line). Bottom: Time-course of normalized I_hold before and during LTX^N4C application (n = 7). Dashed line—baseline I_hold, gray line—application of LTX^N4C. (B) Summary graphs showing an increase in tonic GABA_A current with increasing synaptic release (ΔI_hold/ΔI_spont). The increase in the ΔI_hold/ΔI_spont ratio during NO711 (n = 6) application suggests that more GABA escapes the synapses when mGAT1 is blocked. SNAP5114 (n = 7) had no effect on the ΔI_hold/ΔI_spont ratio, suggesting that mGAT3/4 does not regulate GABA escape from the synapses. ^*P < 0.05, N.S. P > 0.05, unpaired t-test.