Figure 7.

LTX^N4C-mediated increase in I_hold is blocked by GABA_A receptor antagonists. (A) Top: Representative traces showing that picrotoxin (PTX, black solid line) completely blocks the increase in I_hold produced by LTX^N4C (gray line). Dashed line—baseline I_hold. Bottom: Effect of PTX and LTX^N4C on I_hold normalized to the baseline (dashed line, n = 4). Solid black line—application of PTX, solid gray line—application of LTX^N4C. (B) Top: Representative traces showing no increase in I_hold by LTX^N4C (gray line) in the presence of bicuculline (BMI, black solid line). Dashed line—baseline I_hold.Bottom: Effect of BMI and LTX^N4C on I_hold normalized to the baseline (dashed line, n = 4). Solid black line—application of BMI, solid gray line—application.