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Replication checkpoint sensors and transducers.
| Function | S. cerevisiae | S. pombe | H. sapiens |
|---|---|---|---|
| Sensors | Rfa1 | Ssb1 | RPA70 |
| Rfa2 | Ssb2 | RPA32 | |
| Rfa3 | Ssb3 | RPA14 | |
| Apical kinases and interacting proteins | Mec1 | Rad3 | ATR |
| Tel1 | Tel1 | ATM | |
| Ddc2 | Rad26 | ATRIP | |
| Transducers | Mrc1 | Mrc1 | CLASPIN |
| Rad9 | Crb2 | – | |
| Effector kinases | Rad53 | Cds1 | CHK2 |
| Chk1 | Chk1 | CHK1 | |
| Dun1 | – | – |
