Table 2.
Checkpoint kinases phosphorylation targets overview.
| Checkpoint kinase | Regulated process | Targets |
|---|---|---|
| Mec1 | DNA replication | Cdc2, Dpb4, Mcm4, Pol31, Psf1, Rfa1, Rfa2 |
| Checkpoint response | Ddc2, Dun1, Mec1, Mec3, Mrc1, Rad9, Rad17, Rad53 | |
| DNA repair | Mlh1, Msh6, Rad23, Rad26, Rad55, Rtt107, Sae2, Slx4 | |
| dNTP pools regulation | Ssn6 | |
| Chromatin structure | Abf1, Hta1, Ies4, Isw2, Sin3, Sir4, Swi3 | |
| NPC function | Hpr1, Nup2, Nup60 | |
| Other | Cbf1, Cdc13, Nma111, Rif1, Spt7, Sum1 | |
| Rad53 | DNA replication | Sld3, Rad27, Dbf4, Ctf4, Pol1 |
| Checkpoint response | Ddc1, Ddc2, Dun1, Mrc1, Rad9, Rad53, Tof1 | |
| DNA repair | Exo1, Rad54, Rad55, Rtt107 | |
| dNTP pools regulation | Crt1, Nrm1, Rnr3, Swi6 | |
| Chromatin structure | Hhf1, Hho1, Hpc2, Esc1, Fun30, Itc1, Rph1, Snf2 | |
| NPC function | Mlp1, Nsp1, Nup1, Nup2, Nup60, Hpr1 | |
| Other | Mcd1, Plm2, Ycg1 | |
| Dun1 | Checkpoint response | Dun1 |
| DNA repair | Nej1 | |
| dNTP pool regulation | Crt1, Dif1, Rnr3, Sml1 | |
| Chromatin structure | Hpc2, Rco1 | |
| NPC function | Mlp1, Nup159 | |
| Other | Ecm21, Npl3, Sec3 |