Fig. 1.

Dose determination of dieldrin IC₂₀ for functional profiling. (A) The chemical structure of dieldrin. (B) Representative growth curves for the BY4743 wild-type strain treated with dieldrin in YPD media. Curves were performed for 200, 300, 400, 500, 600, and 800μM dieldrin, but for clarity, only the 200, 500, and 800μM doses are shown. (C) The area under the curve (AUC) at each dose was expressed as the mean and SE of three independent experiments and plotted as a percentage of the untreated control. Dashed lines indicate the dose (460μM) at which growth was inhibited by 20% (IC₂₀).