Fig. 7.

Altered Ras/PKA, but not Tor signaling, causes dieldrin sensitivity. Relative growth ratios (treatment vs. control) to the GFP-expressing wild-type strain were obtained. All data represent the mean and SE for three independent YPD cultures treated with the dieldrin IC₂₅ (690μM). Statistical significance between dieldrin-treated wild-type and mutant strains were determined with Student’s t-test, where ^a p < 0.001 and ^b p < 0.01. Statistical differences between a dieldrin-treated strain versus the same strain treated with dieldrin and leucine are shown as *p < 0.05. (A) Dieldrin does not affect strains lacking components involved in Tor signaling. (B) Strains unable to negatively regulate Ras or PKA are sensitive to dieldrin.